Differential expression of p63 isoforms in female reproductive organs

Differential expression of p63 isoforms in female reproductive organs

p63 is the identity switch for uterine/vaginal epithelial cell fate, and disruption of p63 expression by diethylstilbestrol (DES) induces cervical/vaginal adenosis in mice. In this article, we report the expression patterns of p63 isoforms (TA, DeltaN, alpha, beta and gamma) in mice, focusing on the reproductive tract. We also present the reproductive tract phenotype of female p63-/- mice. Fina...

Traumatic Wounds of the Female Reproductive Organs.

Developmental effects of ethinylestradiol on reproductive organs of female mice.

Reproductive organs in female mice are susceptible to exposure to estrogenic substances especially during development. In the present study, C57BL/6J female mice were exposed to the synthetic estrogens ethinylestradiol (EE2) or diethylstilbestrol (DES), 10-100 or 6.7-67 microg/kg bw, respectively, in utero from day 10 to 18 of pregnancy, and their effects were analyzed at 30 and 40 days of age....

An Immunohistochemical Study Of P63 Protein Expression In Meningioma

  Background and Objective: Histological grading has prognostic and therapeutic implications in meningioma. However, histological criteria are sometimes not fulfilled to predict the biological behavior of meningiomas. P63 gene is a novel P53 family member, known as tumor suppressor factor, with multiple isoforms and shows high expression in many normal and neoplastic human tissues. In this stu...

Expression analysis of three h-type thioredoxin isoforms in three Iranian grape (Vitis vinifera L.) cultivars, indicating differential expression in different tissues

Thioredoxins (Trxs) are small ubiquitous disulfide reductases that participate in dithiol-disulfide exchange reactions. In contrast to animals and prokaryotes that typically possess one or a few genes encoding Trxs, higher plants contain eight different Trx types: f, m, x, y, z, o, s, and h. Trx h with multiple forms is involved in different processes such as seed germination, cellular protecti...